AM-168 Anti-HER3 mAb

AM-168
New Drug
AM-168 Anti-HER3 mAb

Indications:

Resistance to Anti-EGFR or Anti-HER2 therapies in breast cancer and lung cancer

  • Development progress

    1. Discovery

    2. Pre-clinical

    3. Phase I

    4. Phase II

Solid tumor

Indications

Resistance to Anti-EGFR or Anti-HER2 therapies in breast cancer and lung cancer

Development progress

Discovery Phase

Detail

Human epidermal growth factor receptor 3 (HER3), a membrane-bound receptor tyrosine kinase disrupted in multiple cancers, including breast, lung and colorectal cancers, among others. HER3 controls a critical signal transduction and drug tolerance pathway, allowing cancer cells to escape from the effect of drugs against other HER family. The HER3 pathway is activated by binding the heregulin (HRG) with the HER3. High expression of HER3 in tumor tissues can be observed in patients who acquired resistance to HER family target therapies, such as cetuximab and trastuzumab. Therefore, HER3, as a key node in cellular signaling networks, is expected to be a prime target for cancer drug development.
AM-168 is a fully human anti-HER3 therapeutic antibody. In vitro and in vivo functional tests show that AM-168 can block the HER3 pathway by preventing the binding between HRG and the HER3. Additionally, administration of AM-168 demonstrated significant growth inhibition of xenograft tumors as monotherapy or in combination with other HER family inhibitors. AM-168 acting against HER3 has great potential as a novel agent for the treatment of solid tumors that bear resistance to EGFR or HER2.

BACK


Verification

Click the numbers in sequence.

academab.com may set and access academab.com cookies on your computer.  Cookies are used to provide our system with the basic information to provide the services you are requesting.  Cookies can be cleared at any time from your internet browser settings. 

 

Cookies Cookies

Privacy preference center

academab.com may set and access academab.com cookies on your computer.  Cookies are used to provide our system with the basic information to provide the services you are requesting.  Cookies can be cleared at any time from your internet browser settings. 

 

Privacy Privacy

Manage Consent Settings

Necessary Cookies

Enable All

網站運行離不開這些 Cookie 且您不能在系統中將其關閉。通常僅根據您所做出的操作(即服務請求)來設置這些 Cookie,如設置隱私偏好、登錄或填充表格。您可以將您的瀏覽器設置為阻止或向您提示這些 Cookie,但可能會導致某些網站功能無法工作。