Human Antibody Mouse

AcadeMab’s antibody mouse is developed by the replacement of the original mouse antibody genes to human antibody genes. This mouse strain can generate human antibodies that have been optimized naturally through in vivo affinity maturation. It can generate a wide variety of therapeutic antibodies from the transgenic mouse via hybridoma cell or single B cell selection. Therefore, it is a powerful tool to provide highly productive, developmental, and customized therapeutic antibodies to the global biopharmaceutical industry.

FEATURE

The human antibodies can be generated via conventional hybridoma technology, which is user-friendly.
The antibody affinity maturation can naturally occur, leading to high affinity clones, via the immunization and boosting of the exotic antigen.

APPLICATION

For developing therapeutic antibodies against specific antigen or pathogen via either hybridoma technology or single B cell selection.

STATUS

AcadeMab’s human antibody mouse is able to express a part of human antibodies. We are still working on optimization of the mouse to generate high diversity antibodies. With this platform, AcadeMab offers the service to screen human antibodies for clients and is seeking partners for out-licensing or co-development in the future.

SB-001 Anti-COVID-19 mAb

SB001 neutralizing human antibodies targeting the RBD domain of SARS-CoV-2 spike protein have potential in prophylactic or therapeutic applications for COVID-19.

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